Hotel Details
401 N 3rd Street, Hannibal, Missouri 63401-3301 United States

Hotel Overview

Located in the heart of historic Hannibal, this hotel places guests within walking distance of the Mark Twain Boyhood Home and Museum, downtown shops, and local cafes. Its central location makes it easy to explore the city's literary heritage, attend popular events such as Tom Sawyer Days, the Big River Steampunk Festival, and the October Folklife Festival, or visit nearby Rockcliffe Mansion.

Guest rooms feature flat-screen TVs, microwaves, and coffee makers for added convenience. Amenities include an indoor pool, hot tub, seasonal outdoor pool, fitness center, and complimentary hot breakfast. With comfortable accommodations and easy access to Hannibal's most popular attractions, the hotel provides a convenient base for exploring this Mississippi River town.

Guest Rooms

Popular rooms offered at this hotel.

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Hotel Amenities

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Location

Hotel location and the surrounding area

401 N 3rd Street
Hannibal, Missouri

Nearby Attractions

Area Business

  • 11.90 mile(s) from BASF, a key employer in Hannibal’s industrial landscape, supporting agricultural solutions. Nearby access makes it convenient for traveling professionals and vendor visits.
  • 3.00 mile(s) from American Cyanamid, part of the area’s chemical and agricultural legacy, this site reflects Hannibal’s working roots. A short drive supports easy access for business-related stays.
  • 3.20 mile(s) from Continental Cement, overlooking the Mississippi, this major cement producer is tied to river commerce. Close enough for quick commutes, it’s ideal for project teams and contractors.
  • 4.70 mile(s) from General Mills, a familiar name with local operations supporting food production. Just minutes away, it’s convenient for visiting staff and partners working in the Hannibal area.
  • 4.00 mile(s) from Jones Poultry, a regional poultry operation supporting local agriculture. Easy access from the hotel makes it a practical stay for vendors and industry partners.
  • 4.10 mile(s) from Watlow, a global manufacturer with a strong Hannibal presence. Its nearby location makes the hotel a comfortable, convenient base for engineers and visiting teams.
  • 7.50 mile(s) from Central Stone, supporting construction across the region, this local supplier is a quick drive away. Ideal for crews and professionals needing easy access to job sites.

Attractions

  • 0.10 mile(s) from Mark Twain Boyhood Home & Museum, step into Twain’s early life in this preserved home and museum. Located downtown, it’s an easy, meaningful stop that brings Hannibal’s literary roots to life.
  • 0.20 mile(s) from Mark Twain Riverboat , enjoy scenic cruises on the Mississippi River with classic Twain narration. Just minutes away, it’s a relaxing way to experience Hannibal’s riverfront charm.
  • 0.10 mile(s) from Becky Thatcher House, explore the childhood home tied to Twain’s beloved character. Right downtown, it’s a charming stop that pairs perfectly with nearby historic sites.
  • 0.30 mile(s) from Hannibal Murals, stroll along the riverfront to see colorful murals depicting local history. Just minutes away, they add a vibrant, walkable touch to the downtown experience.

Dining

  • 4.70 mile(s) from Fiddlesticks Food & Spirits Company, fast casual, American, Sunday 10:45 a.m. to 9:00 p.m., Monday 10:45 a.m. to 9:00 p.m., Tuesday 10:45 a.m. to 9:00 p.m., Wednesday 10:45 a.m. to 9:00 p.m., Thursday 10:45 a.m. to 9:00 p.m., Friday 10:45 a.m. to 9:00 p.m., Saturday 10:45 a.m. to 9:00 p.m., a lively local favorite serving American comfort food with creative flair. Warm, welcoming atmosphere with a touch of Hannibal charm, perfect for relaxing after a day exploring the riverfront and historic downtown.
  • 0.20 mile(s) from Brick Oven, fast casual, Italian, Sunday 12:00 p.m. to 8:00 p.m., Monday closed, Tuesday 4:00 p.m. to 9:00 p.m., Wednesday 4:00 p.m. to 9:00 p.m., Thursday 4:00 p.m. to 9:00 p.m., Friday 11:00 a.m. to 9:00 p.m., Saturday 11:00 a.m. to 9:00 p.m., known for its hand‑tossed pizzas and Italian comfort dishes, this cozy spot blends casual dining with brick oven flavor. A go‑to for guests craving hearty meals in a laid‑back, neighborhood setting.
  • 0.20 mile(s) from Java Jibe, café / coffee shop, American, Sunday 7:00 a.m. to 8:00 p.m., Monday 6:30 a.m. to 9:00 p.m., Tuesday 6:30 a.m. to 9:00 p.m., Wednesday 6:30 a.m. to 9:00 p.m., Thursday 6:30 a.m. to 9:00 p.m., Friday 6:30 a.m. to 9:00 p.m., Saturday 7:00 a.m. to 8:00 p.m., a cheerful coffeehouse offering fresh brews, pastries, and light bites. Its artsy, relaxed vibe and local feel make it a great stop to start your morning or recharge while exploring Hannibal’s historic district.
  • Across the street, Wayne BBQ, casual dining, Bbq, Sunday closed, Monday closed, Tuesday 11:00 a.m. to 8:00 p.m., Wednesday 11:00 a.m. to 8:00 p.m., Thursday 11:00 a.m. to 8:00 p.m., Friday 11:00 a.m. to 8:00 p.m., Saturday 11:00 a.m. to 8:00 p.m., a true taste of Hannibal with slow‑smoked meats and rich, bold flavors. Casual and inviting, it’s a must‑visit for barbecue lovers looking to experience authentic, local cooking with friendly Midwestern hospitality.
  • 0.20 mile(s) from Lulabelles, Full Service, American, Open for: lunch, dinner
  • 0.20 mile(s) from Jumping Frog, Deli, American, Open for: lunch
  • 2.00 mile(s) from TJ's Supper Club, Full Service, American, Open for: lunch, dinner
  • 2.00 mile(s) from Gran Rio, Full Service, Mexican, Open for: lunch, dinner
  • 2.00 mile(s) from Royal Garden, Full Service, Chinese, Open for: lunch, dinner
  • 5.00 mile(s) from Fiddlestik, Full Service, American, Open for: lunch, dinner

Education

  • 3.00 mile(s) from Hannibal LaGrange College, a scenic campus overlooking the Mississippi, known for its close‑knit feel. Just minutes away, it’s convenient for campus visits, events, and staying connected to Hannibal’s academic community.
  • 20 mile(s) from Quincy University
  • 19.30 mile(s) from John Wood Community College, a welcoming local campus offering workforce programs and classes. Close by and easy to reach, it’s a practical choice for visiting faculty, students, and those attending events or trainings.
  • 20 mile(s) from Vatterott College
  • 20 mile(s) from Blessing Rieman College of Nursing
  • 30 mile(s) from Culver-Stockton College
  • 70 mile(s) from Moberly Area Community College, Moberly campus
  • 80 mile(s) from Westminster College
  • 100 mile(s) from University of Missouri

Nearby Cities

  • 21.50 mile(s) from Quincy, IL, a lively Mississippi River city with dining, shopping, and historic streets. An easy drive south makes it a great add‑on for guests wanting more riverfront charm and local flavor.
  • 65.40 mile(s) from Keokuk, iA, set where the Des Moines meets the Mississippi, Keokuk offers scenic river views and quiet charm. A relaxed drive north adds a unique small‑town stop to your stay.
  • 67.40 mile(s) from Jacksonville, IL, rich in history and college-town character, Jacksonville features beautiful architecture and museums. Worth the drive for guests seeking a deeper look into central Illinois heritage.
  • 12.60 mile(s) from Palmyra, MO, a nearby small town with classic Midwest charm and local shops. Just minutes away, it’s a quick, easy side trip for a quieter pace beyond Hannibal.
  • 30.60 mile(s) from LaGrange, MO, a quaint river town along the Mississippi with peaceful views and historic touches. An easy drive north offers a scenic escape and a slower, authentic riverside experience.

Recreation

  • 2.50 mile(s) from Mark Twain Cave, explore Missouri’s oldest show cave, tied to Twain’s stories. Cool, winding passages and guided tours make it an easy, memorable adventure just minutes from the riverfront.
  • 2.10 mile(s) from Sodalis Nature Preserve, a peaceful spot with walking trails and native wildlife. Close by, it’s perfect for a quiet break outdoors while still staying near Hannibal’s main attractions.
  • 1.90 mile(s) from Sawyer's Creek, a hidden gem for light fishing and nature views. Just a short drive, it offers a relaxing, local outdoor escape away from the busier riverfront.
  • 2.30 mile(s) from Cave Hollow Winery, set near the caves, this laid‑back winery offers local wines and scenic surroundings. A quick trip makes it an easy way to unwind with a taste of the region.
  • 2.40 mile(s) from Cameron Cave, a more rugged cave experience next to Mark Twain Cave. Ideal for adventurous guests looking to explore deeper underground in a unique Hannibal setting.
  • 0.40 mile(s) from Mississippi Mine Trap Escape Room, a fun, interactive challenge in downtown Hannibal. Just minutes away, it’s a great group activity that adds a playful twist to your stay.
  • 3.00 mile(s) from Huckleberry Park, a family-friendly park with trails and open green space. Close and easy to reach, it’s a great spot to relax or enjoy outdoor time near town.
  • 4.40 mile(s) from Veterans Park, a scenic riverside park honoring local heroes. Within minutes, it offers peaceful views of the Mississippi and a reflective, walkable setting.

Shopping

  • 0.10 mile(s) from T'S & Trivia
  • 0.10 mile(s) from Rags To Riches, pawnshop
  • 0.20 mile(s) from Native American Trading
  • 0.20 mile(s) from Ayers Pottery
  • 0.20 mile(s) from Groomingdales, pet boutique
  • 0.20 mile(s) from Hickory Stick Quilt Shop
  • 2.00 mile(s) from Steamboat Bend Shopping Center , a convenient stop for everyday needs with familiar retailers and easy parking. Just minutes from the hotel, it’s a practical place to grab essentials while staying close to Hannibal’s main routes.
  • 2.50 mile(s) from Huck Finn Shopping Center, a handy local shopping hub with casual dining and quick stops all in one place. Close by and easy to access, it’s perfect for picking up what you need between exploring Hannibal’s attractions.
  • 3.00 mile(s) from Riverbend Shopping Center
  • 20.00 mile(s) from Quincy Mall

Transportation

  • 123.00 mile(s) from St Louis Lambert International Airport
  • 28.00 mile(s) from Quad Cities International Airport
  • 25.00 mile(s) from Quincy Regional Baldwin Field
  • 2.50 mile(s) from Trailways at Burger King
  • 17.00 mile(s) from Amtrak Quincy Station

Frequently Asked Questions

Q. Does the Best Western On the River offer breakfast?
The Best Western On the River includes a free breakfast, served daily.
Q. Is the Best Western On the River Pet Friendly?
Pets are not accepted.
Q. What time is Check-in at the Best Western On the River?
Check-in time at the Best Western On the River is 03:00 P.M.
Q. What time is Check-out at the Best Western On the River?
Check-out time at the Best Western On the River is 11:00 A.M.
Q. Does the Best Western On the River have free Wi-Fi?
Yes, we offer free Wi-Fi throughout the hotel and all guest rooms.  
Q. Does the Best Western On the River have a pool?
Yes, enjoy our pool
Q. Does the Best Western On the River have a fitness center?
Yes, the Best Western On the River is pleased to offer guests a fitness center/health club