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Hotel Overview

Conveniently located off I-95, this Santee hotel offers cozy guest rooms and easy access to area attractions, including golf courses and state parks.

Rated number one on TripAdvisor for the Town of Santee, the Best Western Plus Santee Inn offers spacious, comfortable and well-appointed guest rooms, each ground-level room complete with parking just outside your door, cable satellite television with HBO® and free high-speed Internet access. Other amenities at this Santee State Park hotel also include a complimentary deluxe continental breakfast each morning, an outdoor heated swimming pool and an on-site restaurant for grabbing a quick bite to eat.

Traveling on business? The Best Western Plus Santee Inn is the perfect stop to rest and relax while traveling along the East Coast, and we even offer meeting facilities for a more productive stay.

While staying in town, be sure to visit local area attractions that surround this hotel in Santee, including Santee State Park, the National Wildlife Refuge, beautiful Lake Marion and more. Plus with many golf courses located just two miles away, like Santee Cooper Golf Resort and National Golf Course, if you are looking to get some time in on the fairways this is the place!

When visiting Santee, South Carolina, there's only one place to stay, the Best Western Plus Santee Inn. Make your reservations online today to save at this spectacular hotel with a convenient location along I-95. Enjoy your stay.

TripAdvisor Certificate of Excellence Badge
TripAdvisor Travelers Choice Award

Hotel Amenities

Because We CareSM

Cleaning Standards

Industry-Leading Cleaning Standards

Modified Breakfast

Breakfast Service & Selections 

Low Rate Guarantee

Low Rate Guarantee

Hotel Policies

Pet Policy
Pets may be accepted. Please contact the hotel directly for full details.
Child Policy
Children 12 And Under Are Free In Room With One Paying Adult In Existing Bedding.


Hotel location and the surrounding area

Nearby Attractions


  • 2.00 mile(s) from Santee State Park
  • 4.00 mile(s) from National Wildlife Refuge


  • Adjacent to Captain's Quaters, full service, Steak House, open for: dinner, fine dining experience adjacent to hotel lobby specializing in steak & seafood, also including full service bar.
  • Adjacent to Kentucky Fried Chicken, fast food, American, open for: lunch, dinner,
  • Adjacent to Shoney's, buffet, American, open for: breakfast, lunch, dinner,
  • Across the street from La Fogata, full service, Mexican, open for: dinner,
  • 0.50 mile(s) from Cracker Barrel, full service, American, open for: breakfast, lunch, dinner,
  • 0.50 mile(s) from Coasters, bar/lounge, American, open for: dinner,
  • 0.50 mile(s) from Lt's, bar/lounge, American, open for: dinner,

Nearby Cities

  • 15.00 mile(s) from Holley Hill
  • 20.00 mile(s) from Manning
  • 25.00 mile(s) from Orangeburg
  • 60.00 mile(s) from Charleston


  • 0.10 mile(s) from Lake Marion Golf Course
  • 1.00 mile(s) from Lake Marion, world-famous bass fishing
  • 1.00 mile(s) from Santee Cooper Golf Resort
  • 2.00 mile(s) from National Golf Course


  • 1.00 mile(s) from Santee Village Outlet Mall


  • 60.00 mile(s) from Columbia Metro Airport