120 S Interstate Drive
Sikeston, Missouri 63801-8641
United States


Toll Free Reservations (US & Canada Only)

Worldwide Numbers

Hotel Direct Number


3:00 P.M. CST


11:00 A.M. CST



Hotel Overview

TripAdvisor Certificate of Excellence Badge
TripAdvisor Travelers Choice Award

Convenience and service make this Sikeston hotel a popular favorite that's close to Interstates 55 and 57 and Highway 62.

Your Best Western Plus Sikeston is pet-friendly, welcoming the entire family whether it’s for a vacation or business trip. Hotels in Sikeston are renowned for hospitality, but the bar is set high at this property. Near the Sikeston Rodeo, there are endless entertainment options that draw travelers from around the country. Business travelers and leisure travelers alike enjoy the homey amenities and great customer service.

Looking for the best Sikeston, MO hotels? Our property is affordable and boasts the absolute best service in town. A popular stopping point for travelers, make sure to visit some local favorites like Lambert’s Café, just a few minutes away from this Sikeston hotel. The Azalea Festival is a favorite local event, and there’s always something special happening nearby. Ask a friendly staff member for recommendations or an insider’s tip on must-see destinations.

Business travelers with Tyson Foods and Unilever depend on our Sikeston hotel for extended stays. Offering corporate travelers and government employees, such as those with BNSF, the best rates in town guarantees a stress-free trip. Newly renovated and just 20 miles to the Mississippi River, you deserve only the best Sikeston hotel on your next trip. Plus, staying 30 miles to the nearest casino means the best in gaming and entertainment is a short commute away.

Reserve your next stay at Best Western Plus Sikeston where the comfort of guests is a top priority! Enjoy your stay.

Hotel Amenities

Because We CareSM

Cleaning Standards

Industry-Leading Cleaning Standards

Modified Breakfast

Modified Breakfast Service & Selections (varies by hotel)

Low Rate Guarantee

Low Rate Guarantee

Hotel Policies

Pet Policy
Pets allowed based on the availability of pet friendly rooms. Up to 2 dogs per room with a 80 pound weight limit. Additional pet types (cats, birds, etc) may be accepted at the hotel’s discretion. Pet rate is $15.00 per day with a $100 per week maximum.
Child Policy
Children 17 And Under Are Free In Room With One Paying Adult In Existing Bedding.


Hotel location and the surrounding area

Nearby Attractions

Area Business

  • 0.05 mile(s) from Steward Steel, 101 N. Interstate Drive, Sikeston, MO. 573-471-2121
  • 0.05 mile(s) from FedEx® Shipping Center, 2830 E Malone, Sikeston, MO.
  • 2.00 mile(s) from Tetra Pak®, 2200 E. Malone Avenue, Sikeston, MO. 573-471-1441
  • 4.00 mile(s) from Unilever® South Plant, 1000 County Line Road Sikeston, MO. 573-471-7051
  • 5.00 mile(s) from Cott Beverage, 301 Larcel Drive, Sikeston, MO 573-471-4445
  • 6.00 mile(s) from Atlas Cold Storage, 2500 Rose Parkway, Sikeston, MO 573-471-7727
  • 6.00 mile(s) from Americold® Logistics, 2500 Rose Parkway, Sikeston, MO. 573-471-7727
  • 6.00 mile(s) from Missouri Department of Tr, 2675 N. Main Street, Sikeston, MO. 573-472-5333
  • 6.00 mile(s) from Do it Best, 2600 Rose Parkway, Sikeston, MO. 573-472-5770
  • 6.00 mile(s) from Unilever® North Plant, 2400 Rose Parkway, Sikeston, MO.
  • 6.00 mile(s) from Cargill®, 410 W. Malone Avenue, Sikeston, MO. 573-472-2272
  • 7.00 mile(s) from Orgill, 2727 N. Main Street, Sikeston, MO. 573-471-2071
  • 8.00 mile(s) from Alan Wire, 814 S. West Street, Sikeston, MO. 573-471-9548
  • 20.00 mile(s) from Tyson® Foods, 1001 E. Stoddard Street, Dexter, MO.


  • 3.00 mile(s) from The Sikeston Depot Museum, 116 W Malone, Sikeston. Housed in the city's historically renovated train depot on one of the first rail lines constructed west of the Mississippi River, the depot features a historic museum recounting the most important aspect of the area's culture; an art gallery in which local artists display their work; and a cultural center displaying traveling exhibits from national museums. Free Admission.
  • 7.00 mile(s) from Southeast Missouri Agricultural Museum and Granny's Antiques, County Road 521, Bertrand, MO. 6,000 plus pieces of antique farm equipment. Indoor display areas include main museum and five outer buildings of great historic interest, including two Missouri log cabins (circa 1880), one wooden railroad caboose, one related railroad depot, and a reconstructed 1920's service station.
  • 4.00 mile(s) from The Columns, N. New Madrid Street, Downtown. These six majestic pillars stand as a monument to the city's religious heritage and the beautiful First Methodist Church, which was erected in 1879 and tragically destroyed by fire in 1968. This church's congregation represented the first Methodist church west of the Mississippi River.
  • 3.00 mile(s) from Jaycee Bootheel Rodeo, 1220 N Ingram Rd, Sikeston, MO 63801. Join the Jaycee Bootheel Rodeo in August for the PRCA sanctioned rodeo. The largest in the state and one of the largest in the USA. Hosts nationally known country music nightly.


  • 1.00 mile(s) from Lambert's Cafe, cafe, American, open for: lunch, dinner, "The only home of the throwed rolls®". Try some of Lambert's favorite pass-arounds. Throwed Rolls, Sorghum Molasses, Black-eyed Peas, Fried Okra, Macaroni & Tomatoes and Fried Potatoes. Open seven days a week from 10:30 a.m. to 9:00 p.m.
  • 1.00 mile(s) from El Tapatio, bar/lounge, Mexican, open for: lunch, dinner, Monday-Saturday 11 a.m. to 10 p.m. and Sunday 11 a.m. to 9:30 p.m.
  • 0.50 mile(s) from Ruby Tuesday, full service, American, open for: lunch, dinner
  • 4.00 mile(s) from China Buffet, buffet, Chinese, open for: lunch, dinner, largest selection and best prices in town. Dinner buffet: catfish, fried shrimp, frog legs.
  • 3.00 mile(s) from Grecian Steak House, buffet, American, open for: lunch, dinner, numerous item salad and dessert bar. Hot food bar, ice cream and sundae bar. All free with dinner.
  • 4.00 mile(s) from El Bracero®, full service, Mexican, open for: lunch, dinner, authentic Mexican restaurant. Happy hour daily 3 p.m. to close. Lunch specials.
  • 4.00 mile(s) from Kirby's Sandwich Shop, cafe, American, open for: lunch, since 1907. Burger baskets, etc. In our historic downtown area. Mom & Pop style cafe.
  • 4.00 mile(s) from Susie's Bake Shoppe, cafe, American, open for: lunch, homemade bakery products. Daily specials. Fresh baked desserts. Fitness selections. In our historic downtown area.
  • 4.00 mile(s) from Applebee's®, full service, American, open for: lunch, dinner
  • 4.00 mile(s) from Jeremiah's, full service, American, open for: lunch, dinner, fine dining and spirits. In our historic downtown area.
  • 2.00 mile(s) from Cheers Bar & Grill, Inc., bar/lounge, American, open for: lunch, dinner, also has an area for families that dont want to eat in the bar/grill area.
  • 3.00 mile(s) from Dexter Bar-B-Que, cafe, American, open for: lunch, dinner
  • 3.00 mile(s) from Jay's Krispy Fried Chicken, cafe, American, open for: breakfast, lunch, dinner, one of the two main breakfast cafes in town.
  • 2.50 mile(s) from Pizza Hut®, full service, American, open for: lunch, dinner, hours Sunday-Thursday 11 a.m. to 10 p.m. and Friday and Saturday 10 a.m. to 11 p.m.
  • 1.50 mile(s) from Pizza Inn®, buffet, American, open for: lunch, dinner


  • 3 mile(s) from Three Rivers Community College
  • 8 mile(s) from Southeast Missouri State, four year university

Nearby Cities

  • 13.00 mile(s) from Charleston
  • 53.00 mile(s) from Poplar Bluff
  • 55.00 mile(s) from Caruthersville
  • 60.00 mile(s) from Paducah, Kentucky
  • 60.00 mile(s) from Perryville
  • 65.00 mile(s) from Blytheville, Arkansas
  • 70.00 mile(s) from Metropolis, Illinois
  • 140 mile(s) from St. Louis
  • 150 mile(s) from Memphis, Tennessee
  • 13.00 mile(s) from Benton
  • 265 mile(s) from Branson
  • 20.00 mile(s) from New Madrid
  • 20.00 mile(s) from Dexter
  • 30.00 mile(s) from Cape Girardeau
  • 40.00 mile(s) from Jackson


  • 2 mile(s) from Recreation Complex, The City's most complete outdoor recreational facility, it offers mobility accessible playground equipment, a tot lot for preschool children, lighted tennis courts, sand volleyball courts, horseshoe pits, soccer fields, unlighted T-ball fields, lighted softball fields, a lighted Junior Babe Ruth baseball field, an outdoor basketball court, 4.6 acre fishing lake, half-mile fitness trail, picnic shelters with charcoal grills, drinking fountains, and restroom facilities.
  • 2 mile(s) from Sikeston Country Club, Tee off at one of the finest county club courses in Southeast Missouri. The Sikeston Country Club features an 18 hole, 71 par, semi-private golf course with pro shop. East Malone, Sikeston
  • 2 mile(s) from Sikeston Blowing Center, 1601 East Malone Sikeston 573-471-2430
  • 2.5 mile(s) from Malco Trio Cinema, 1045 East Malone in the Midtowner Shopping Center. 573-471-8420
  • 3.5 mile(s) from YMCA, 511 Taylor Street, Sikeston Facilities include a fitness center, an aquatic center that has a 6-lane pool, 15 foot high water slide, a three-lane wide walking track, a gymnasium used for basketball and volleyball, nursery, locker rooms and sauna.


  • 0.50 mile(s) from Sikeston Factory Outlet, Kitchen Collection®, Famous Footwear®, 50 Off, Carter's®, VF® Outlet, Rue 21®, G.H. Bass & Co.®, Fashion Nails, dressbarn®, L'eggs, Hanes®, Bali® & Playtex®
  • 1.50 mile(s) from Judy's Fashions, 2107 East Malone, Sikeston. Family clothing store and consignment shop.
  • 2.00 mile(s) from Factory Connections, Malone Avenue, Sikeston. Men's & women's clothing store.
  • 4.00 mile(s) from Walmart® Superstore, South Main, Sikeston.
  • 4.00 mile(s) from Cato, South Main, Sikeston. Women's clothing store.
  • 3.50 mile(s) from Sikes Sporting Goods, 207 North New Madrid Street, Sikeston.
  • 4.00 mile(s) from JC Penney®, 1215 South Main, Sikeston.
  • 4.00 mile(s) from Goody's, South Main, Sikeston. Family clothing store.


  • 154 mile(s) from St Louis Lambert International Airport
  • 56.00 mile(s) from Barkley Regional Airport
  • 4.00 mile(s) from Sikeston Memorial Municipal Airport